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Acetyl-resveratrol

Acetyl-resveratrol

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Synonyms: Acetyl trans-resveratrol; 1,3-Benzenediol,5-[(1E)-2-[4-(acetyloxy)phenyl]ethenyl]-, diacetate (9CI); 1,3-Benzenediol,5-[2-[4-(acetyloxy)phenyl]ethenyl]-, diacetate, (E)-; 3,4',5-Triacetoxy-trans-stilbene; 3,5,4'-Tri-O-acetylresveratrol; Trans-Resveratrol triacetate
Specification: 98%
Appearance: White to off-white powder
Test Method: HPLC
Molecular Formula: C20H18O6
Molecular Weight: 354.35
CAS No: 42206-94-0
Description: Acetyl-resveratrol is called prodrug on medicinal chemistry, it is more stable than trans-resveratrol. When absorbed, it returns to resveratrol under action of metabolism.
The main drawback with current resveratrol forms is the low oral bioavailability. Resveratrol is water-insoluble substance; it can be easily excreted when intaked. This is why finding these acetylated analogs has been so significant; they have better bioavailability and increased biological activity in comparison to the base phenolic compounds. Multiple studies have shown that acetylated analogs of Resveratrol exhibit the same or higher inhibitory effects on various tumor cell lines than Resveratrol itself while being absorbed faster and resisting cellular breakdown. Since the acetylated Resveratrol is being absorbed more quickly, plasma levels in the body reach a higher level and at a faster rate. Through ester hydrolysis enzymes in the body actually break down acetylated Resveratrol back to its natural phenolic form.
Dosage form varied from pill to capsule up to different requirements when use Acetyl-resveratrol as raw material.
Resveratrol is unstable because its Hydroxyls are active group when exposure to oxygen, light and heat. The purpose of acetylation is to inactivate Resveratrol before absorption.
Acetyl-resveratrol is soluble in water (but not resveratrol). Therefore, it can be widely used in cosmetic industry, pharmaceutics, food, beverage, health products.

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